Synthesis of 2-[(5-Amino-1H-pyrrol-2-yl)sulfanyl]acetic Acid Esters: One-Pot Assembly from Propargyl Amines, Isothiocyanates, and Alkyl 2-Bromoacetates was written by Tarasova, Olga A.;Nedolya, Nina A.;Albanov, Alexander I.;Trofimov, Boris A.. And the article was included in Synthesis in 2019.HPLC of Formula: 2253-73-8 The following contents are mentioned in the article:
The compounds 2-[(5-Amino-1 H-pyrrol-2-yl)sulfanyl]acetic acid esters I (R = R1 = Me, Et, Pr; RR1 = -(CH2)4-, -(CH2)5-, -(CH2)2O(CH2)2-; R2 = Me, Et, i-Pr, n-Bu, CH2CH2OCH=CH2; R3 = Me, Et, i-Pr, t-Bu, Bn) have been synthesized in up to 77% yield by the one-pot reaction of lithiated propargylamines RR1NCH2CCH with isothiocyanates R2N=C=S followed by sequential treatment with t-BuOK-DMSO and alkyl 2-bromoacetates BrCH2CO2R3. The process occurs through the initial formation of the thiophene core, followed by its recyclization into the pyrrole nucleus at a higher temperature (ca. 45-60 °C). This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8HPLC of Formula: 2253-73-8).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 2253-73-8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics