External oxidant-free electrooxidative intramolecular S-N bond formation for one-pot synthesis for 3,5-disubstituted 1,2,4-thiadiazoles was written by Zhong, Qihao;Sheng, Shouri;Chen, Junmin. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2020.Safety of Isopropylisothiocyanate The following contents are mentioned in the article:
An electrochem. oxidative reaction protocol for the synthesis of 5-amino and 3,5-diamino substituted 1,2,4-thiadiazole derivatives I (R1 = Ph, cyclopropyl, phenylaminyl, etc.; R2 = Ph, pyridin-4-yl, propan-2-yl, etc.) has been developed under undivided electrolytic conditions. The newly developed one-pot methodol. involves the reaction of isothiocyanates R2NCS with amidines or guanidines R1C(=NH)NH2. HCl to give the corresponding imidoyl thioureas, which are further cyclized in situ via electrooxidative intramol. S-N bond formation to promote the final products. This protocol features a metal- and external oxidant-free approach, broad substrate scope, good functional group tolerance, excellent yields, and one-pot operation/reaction without the isolation of the intermediates. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Safety of Isopropylisothiocyanate).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Safety of Isopropylisothiocyanate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics