Synthesis and anxiolytic activity of some novel benzotriazole derivatives was written by Singh, V. K.;Bharadwaj, Peeyush;Rishishwar, Poonam. And the article was included in Journal of Drug Delivery and Therapeutics in 2019.Synthetic Route of C4H7NS The following contents are mentioned in the article:
1,2,3-Benzotriazole (BTA) is a heterocyclic compound with three nitrogen atoms. It is a polar and colorless compound which can be used for its great versatility. The enormous investigations on derivatives of benzotriazole reveal wide applicability for tagging and delivering a number of heterocyclic nuclei with this mol. In the present work synthesis of several derivatives of 1-(substituted)-5-[(N-benzotriazolomethyl)-1,3, 4-thiadiazolyl]- imidazole-2-thione has been synthesized and are evaluated for their anxiolytic activity. The antianxiety activities of the synthesized derivatives were evaluated using EPM test and Bright and dark box test exptl. models of anxiety. All results were expressed as mean± standard error mean (SEM) and analyzed by one-way ANOVA. Post-hoc comparisons were performed by applying Dunnet′s test. P <0.05 was considered statistically significant. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Synthetic Route of C4H7NS).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Synthetic Route of C4H7NS
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics