Chen, Qian published the artcileSynthesis of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride, Recommanded Product: Ethyl 3-(dimethylamino)acrylate, the publication is Nongyao (2012), 51(8), 569-572, database is CAplus.
This article aims to optimize a reasonable route of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride on industrial scale. 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride was synthesized from Et 3-(dimethylamino)arylate via four steps including acylation, cyclization, hydrolysis, chlorination. The total yield was 46.8%, and the purity of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid was 96.1% (HPLC). The products and intermediates were determined by 1H NMR or MS and so on. The yield is improved and the operation process is simple, which is suitable for industrial production
Nongyao published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Recommanded Product: Ethyl 3-(dimethylamino)acrylate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics