Huang, Lily published the artcileIdentification of Potent and Selective Mechanism-Based Inhibitors of the Cysteine Protease Cruzain Using Solid-Phase Parallel Synthesis, Recommanded Product: Ethyl 2-mercaptopropanoate, the publication is Journal of Medicinal Chemistry (2002), 45(3), 676-684, database is CAplus and MEDLINE.
Targeted libraries of ketone-based cysteine protease inhibitors were synthesized and screened against cruzain, a cysteine protease implicated in Chagas’ disease. A number of single digit nanomolar, low mol. weight inhibitors were identified and optimized for solubility and potency. Specifically, the best inhibitors identified have Ki values of 0.9-10 nM and mol. weights between 499 and 609 Da. The most effective inhibitor was also greater than 1000-fold selective for cruzain relative to cathepsin B and 100-fold selective for cruzain relative to cathepsin L.
Journal of Medicinal Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Recommanded Product: Ethyl 2-mercaptopropanoate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics