Schulte, Bianca published the artcileAndrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti-SARS-CoV-2 Activity, SDS of cas: 624-49-7, the publication is ChemMedChem (2022), 17(5), e202100732, database is CAplus and MEDLINE.
Naturally occurring compounds represent a vast pool of pharmacol. active entities. One of such compounds is andrographolide, which is endowed with many beneficial properties, including the activity against SARS-CoV-2. To initiate a drug repurposing or hit optimization campaign, it is imperative to unravel the primary mechanism(s) of the antiviral action of andrographolide. We showed by means of a reporter gene assay that andrographolide exerts its anti-SARS-CoV-2 effects by inhibiting the interaction between Kelch-like ECH-associated protein 1 (KEAP1) and nuclear factor erythroid 2-related factor 2 (NRF2) causing NRF2 upregulation. Moreover, we demonstrated that subtle structural modifications of andrographolide could lead to derivatives with stronger on-target activities and improved physicochem. properties. Our results indicate that further optimization of this structural class is warranted to develop novel COVID-19 therapies.
ChemMedChem published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C14H10O4, SDS of cas: 624-49-7.
Referemce:
https://en.wikipedia.org/wiki/Ester,
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