Al-Hiari, Yusuf M. published the artcileFluoroquinolones: novel class of gastrointestinal dietary lipid digestion and absorption inhibitors, Name: Ethyl 3-(dimethylamino)acrylate, the publication is Medicinal Chemistry Research (2014), 23(7), 3336-3346, database is CAplus.
Pancreatic triacylglycerol lipase (PL) has been reported as an interesting pharmacol. target for the management of dyslipidemia, atherosclerosis, and obesity. In the current study, a 4-quinoline-3-carboxylic acid system has been identified as a potent inhibitor of PL. Three new fluoroquinolones (11, 12, (I) and 13 (II)) were synthesized and evaluated in vitro with respect to their anti-lipase efficacy and potency properties and gave IC50 values in the range of 18.4-29.1 μM against PL. The IC50 of the standard drug orlistat was 0.2 μM. The inhibitory activities of these compounds were supported by docking studies, which suggested that they acted according to a similar mechanism to that of the known drug orlistat. In conclusion, these effective PL inhibitors could be used to advance the development of anti-obesity drugs via the regulation of the entire gastrointestinal lipolysis process.
Medicinal Chemistry Research published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Name: Ethyl 3-(dimethylamino)acrylate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics