Formulation and bioavailability of benorilate tablets was written by Chen, J.;Tu, X. D.. And the article was included in Yaoxue Xuebao in 1994.Name: 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:
A new formulation tablet B was developed and compared with tablet A with the purpose of improving the bioavailability of benorilate by reducing its particle size. The dissolution rate in vitro was determined by paddle method and using surfactant solution medium. The plasma concentrations of hydrolyzates which are salicylic acid and paracetamol from benorilate in vivo were measured by HPLC. The dissolution rates of ground and unground drug are 0.0337 min-1 and 0.0152 min-1, resp. Compared with tablet A, the cumulative dissolution percentage of B is higher. The mean dissolution time of B and A are 15.77 min and 42.25 min, resp. The study in vivo showed that the Cmax, Tp and AUC of salicylic acid for these two formulations have no significant difference. The relative bioavailability of B to A is 125.59%. Their in vivo process fits one-compartment model and first order elimination. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Name: 4-Acetamidophenyl 2-acetoxybenzoate).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Name: 4-Acetamidophenyl 2-acetoxybenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics