Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1 was written by Benchekroun, Mohamed;Ermolenko, Ludmila;Tran, Minh Quan;Vagneux, Agathe;Nedev, Hristo;Delehouze, Claire;Souab, Mohamed;Baratte, Blandine;Josselin, Beatrice;Iorga, Bogdan I.;Ruchaud, Sandrine;Bach, Stephane;Al-Mourabit, Ali. And the article was included in European Journal of Medicinal Chemistry in 2020.Formula: C4H7NS The following contents are mentioned in the article:
With the aim to develop new chem. tools based on simplified natural metabolites to help deciphering the mol. mechanism of necroptosis, simplified benzazole fragments including 2-aminobenzimidazole and the 2-aminobenzothiazole analogs were prepared during the synthesis of the marine benzosceptrin B. Compounds inhibiting the RIPK1 protein kinase were discovered. A library of 54 synthetic analogs were prepared and evaluated through a phenotypic screen using the inhibition of the necrotic cell death induced by TNF-α in human Jurkat T cells deficient for the FADD protein. This article reports the design, synthesis and biol. evaluation of a series of 2-aminobenzazoles on the necroptotic cell death through the inhibition of RIPK1 protein kinase. The 2-aminobenzimidazole and 2-aminobenzothiazole platforms presented herein can serve as novel chem. tools to study the mol. regulation of necroptosis and further develop lead drug candidates for chronic pathologies involving necroptosis. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Formula: C4H7NS).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C4H7NS
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics