Photolytic degradation of benorylate: effects of the photoproducts on cultured hepatocytes was written by Castell, J. V.;Gomez-L., M. J.;Mirabet, V.;Miranda, M. A.;Morera, I. M.. And the article was included in Journal of Pharmaceutical Sciences in 1987.Formula: C17H15NO5 The following contents are mentioned in the article:
The photodegradation of benorylate [4′-(acetamido)phenyl-2-acetoxybenzoate], a drug frequently used in rheumatoid arthritis therapy, has been examined under different sets of exptl. conditions. Several photoproducts have been isolated and identified on the basis of their IR, NMR, and MS spectra. The most significant photochem. process is the photo-Fries rearrangement of benorylate, leading to 5-acetamido-2′-acetoxy-2-hydroxybenzophenone. This compound undergoes a rapid transacylation to the isomeric 5′-acetamido-2′-acetoxy-2-hydroxybenzophenone. A primary culture of rat hepatocytes has been used to evaluate the possible toxicity of these two benzophenones, keeping in mind the following criteria: leakage of cytosolic enzymes, attachment index to culture plates, gluconeogenesis from lactate and fructose, glycogen balance, and albumin synthesis. At the concentrations assayed, neither of the two major photoproducts of benorylate (benzophenones) had significant toxic effects on liver cells in culture. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Formula: C17H15NO5).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Formula: C17H15NO5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics