Weis, Erik published the artcileLate-Stage Amination of Drug-Like Benzoic Acids: Access to Anilines and Drug Conjugates through Directed Iridium-Catalyzed C-H Activation, Formula: C9H8O4, the publication is Chemistry – A European Journal (2021), 27(72), 18188-18200, database is CAplus and MEDLINE.
The method presented herein enables the amination of a wide array of benzoic acids RC(O)OH (R = 2-fluorophenyl, naphthalen-1-yl, thiophen-2-yl, 2H-1,3-benzodioxol-4-yl, etc.) with high selectivity. The robustness of the system is manifested by the large number of functional groups tolerated, which allowed the amination of a diverse array of marketed drugs and drug-like mols. Furthermore, the introduction of a synthetic handle enabled expeditious access to targeted drug-delivery conjugates, e.g., I, PROTACs II, and probes for chem. biol. This rapid access to valuable analogs, combined with operational simplicity and applicability to high-throughput experimentation has the potential to aid and considerably accelerate drug discovery.
Chemistry – A European Journal published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C6H5F4NO3S, Formula: C9H8O4.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics