Chen, Kai published the artcileEngineered Cytochrome c-Catalyzed Lactone-Carbene B-H Insertion, Computed Properties of 517-23-7, the publication is Synlett (2019), 30(4), 378-382, database is CAplus and MEDLINE.
Previous work has demonstrated that variants of a heme protein, Rhodothermus marinus cytochrome c(Rma cyt c), catalyze abiol. carbene boron-hydrogen (B-H) bond insertion with high efficiency and selectivity. Here authors investigated this carbon-boron bond-forming chem. with cyclic, lactone-based carbenes. Using directed evolution, they obtained a Rma cyt c variant BORLAC that shows high selectivity and efficiency for B-H insertion of 5- and 6-membered lactone carbenes (up to 24,500 total turnovers and 97.1:2.9 enantiomeric ratio). The enzyme shows low activity with a 7-membered lactone carbene. Computational studies revealed a highly twisted geometry of the 7-membered lactone carbene intermediate relative to 5- and 6-membered ones. Directed evolution of cytochrome c together with computational characterization of key iron-carbene intermediates has allowed us to expand the scope of enzymic carbene B-H insertion to produce new lactone-based organoborons.
Synlett published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Computed Properties of 517-23-7.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics