Humphries, Paul S. published the artcilePyridine-3-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents, Synthetic Route of 5340-78-3, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(23), 6120-6123, database is CAplus and MEDLINE.
A series of novel pyridine-3-propanoic acids was synthesized. A structure-activity relationship study of these compounds led to the identification of potent dual PPARα/γ agonists with varied isoform selectivity. Based on the results of efficacy studies in diabetic (db/db) mice, and the desired pharmacokinetic parameters, I [R,R1 = CH2CH2; R = R1 = Me] were selected for further profiling.
Bioorganic & Medicinal Chemistry Letters published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Synthetic Route of 5340-78-3.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics