Cyclodextrin nanosponges inclusion compounds associated with gold nanoparticles for potential application in the photothermal release of melphalan and cytoxan was written by Salazar, Sebastian;Yutronic, Nicolas;Kogan, Marcelo J.;Jara, Paul. And the article was included in International Journal of Molecular Sciences in 2021.Safety of Diphenyl carbonate The following contents are mentioned in the article:
This article describes the synthesis and characterization of β -cyclodextrin-based nanosponges (NS) inclusion compounds (IC) with the anti-tumor drugs melphalan (MPH) and cytoxan (CYT), and the addition of gold nanoparticles (AuNPs) onto both systems, for the potential release of the drugs by means of laser irradiation The NS-MPH and NS-CYT inclusion compounds were characterized using SEM (SEM), X-ray powder diffraction (XRPD), energy dispersive spectroscopy (EDS), thermogravimetric anal. (TGA), UV-Vis, and proton NMR (1H-NMR). Thus, the inclusion of MPH and CYT inside the cavities of NSs was confirmed. The association of AuNPs with the ICs was confirmed by SEM, EDS, TEM, and UV-Vis. Drug release studies using NSs synthesized with different molar ratios of β -cyclodextrin and diphenylcarbonate (1:4 and 1:8) demonstrated that the ability of NSs to entrap and release the drug mols. depends on the crosslinking between the cyclodextrin monomers. Finally, irradiation assays using a continuous laser of 532 nm showed that photothermal drug release of both MPH and CYT from the cavities of NSs via plasmonic heating of AuNPs is possible. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Safety of Diphenyl carbonate).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Safety of Diphenyl carbonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics