Tyrosine-Reactive Cross-Linker for Probing Protein Three-Dimensional Structures was written by Cui, Lili;Ma, Yongge;Li, Ming;Wei, Zhonglin;Huan, Yanfu;Li, Hongmei;Fei, Qiang;Zheng, Lianyou. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2021.SDS of cas: 102-09-0 The following contents are mentioned in the article:
Crosslinking mass spectrometry (XL-MS) has made significant progress in understanding the structure of protein and elucidating architectures of larger protein complexes. Current XL-MS applications are limited to targeting lysine, glutamic acid, aspartic acid, and cysteine residues. There remains a need for the development of novel cross-linkers enabling selective targeting of other amino acid residues in proteins. Here, a novel simple cross-linker, namely, [4,4′-(disulfanediylbis(ethane-2,1-diyl)) bis(1,2,4-triazolidine-3,5-dione)] (DBB) (I), has been designed, synthesized, and characterized. This cross-linker can react selectively with tyrosine residues in protein through the electrochem. click reaction. The DBB cross-links produced the characteristic peptides before and after electrochem. reduction, thus permitting the simplified data anal. and accurate identification for the cross-linked products. This is the first time a cross-linker is developed for targeting tyrosine residues on protein without using photoirradiation or a metal catalyst. This strategy might potentially be used as a complementary tool for XL-MS to probe protein 3D structures, protein complexes, and protein-protein interaction. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0SDS of cas: 102-09-0).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 102-09-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics