Solubilization and changes of physicochemical properties of baicalin by nano sponge, and toxicity of zebrafish liver was written by Song, Jiawen;Long, Jiaying;Xie, Long;Sun, Qiang;Zhang, Linlin;Chen, Huijuan;Deng, Mao;Li, Xiaofang. And the article was included in Journal of Drug Delivery Science and Technology in 2020.HPLC of Formula: 102-09-0 The following contents are mentioned in the article:
As a new type of drug carrier, nano-sponge (NS) can remarkably improve the solubility of poorly soluble drug components, significantly increase the efficacy of drugs and their bioavailability. Baicalin (BA) has many biol. activities, such as anti-inflammatory, bacteriostatic and , etc. But due to its poor solubility, BA cannot play a role in the clinic. Therefore, it is urgent to find a suitable solubilization technol. to improve the solubility of BA. In this paper, we optimized the preparation process of NS based on β-cyclodextrin (β-CD), and then prepared the baicalin nano-sponges (BA-NS). The successful preparation of BA-NS was verified by modern anal. methods. BA loading capacity and efficiency (BLC and BLE), solubilizing effect, in vitro release rate and liver toxicity were investigated. The results showed that the BLC and BLE were 18.02 ± 0.36% and 86.64 ± 0.86%, solubility in water was 31 times than that of pure BA, and release rate in different media could reach 80%. Zebrafish liver toxicity test showed no obvious toxicity. The above results showed that NS had a significant solubilizing effect on BA and was safe and non-toxic, and proved that NS maybe have broad prospects in the research of poorly soluble drugs. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0HPLC of Formula: 102-09-0).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 102-09-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics