Reduction by acetylsalicylic acid of paracetamol-induced hepatic glutathione depletion in rats treated with 4,4′-dichlorobiphenyl, phenobarbitone and pregnenolone-16α-carbonitrile was written by Van Bree, L.;Groot, E. J.;De Vries, J.. And the article was included in Journal of Pharmacy and Pharmacology in 1989.Category: esters-buliding-blocks The following contents are mentioned in the article:
The role of enzyme induction in the reduction by acetylsalicylic acid (ASA) of paracetamol-induced hepatic glutathione (GSH) depletion was studied in rats. Administration of an overdose of paracetamol to control rats resulted in an appreciable decrease of GSH concentration Pretreatment with the enzyme inducers phenobarbitone, 3-methylcholanthrene (3-MC), pregnenolone-16α-carbonitrile and 4,4′-dichlorobiphenyl potentiated the paracetamol-induced depletion of GSH. Simultaneous administration of an equimolar dose of ASA reduced the paracetamol-induced depletion of GSH in all instances except for those rats that were not pretreated and those given 3-MC. Benzorylate, the ASA ester of paracetamol, depressed rat liver GSH to levels comparable to those produced by the combination of paracetamol and ASA. ASA itself caused only minor changes in liver GSH concentrations ASA diminishes paracetamol-induced GSH depletion in rats with a phenobarbitone type of enzyme induction. Inhibition of the formation of the reactive metabolite of paracetamol or reduction of the absorption rate of paracetamol seems to be unlikely as a mechanism underlying the ASA-induced effect. An ASA-mediated effect via changes of the hepatic SH status is proposed. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Category: esters-buliding-blocks).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics