Synthesis, characterization and investigation of the antioxidant activity of some 1,2,4-benzothiadiazine-1,1-dioxides bearing sulfonylthiourea moieties was written by Harrouche, Kamel;Lahouel, Asma;Belghobsi, Mebrouk;Pirotte, Bernard;Khelili, Smail. And the article was included in Canadian Journal of Chemistry in 2019.Application In Synthesis of Isopropylisothiocyanate The following contents are mentioned in the article:
A series of 1,2,4-benzothiadiazine-1,1-dioxides bearing sulfonylthiourea moiety I [R1 = H, Me, Ph, Bn, 4-MeOC6H4; R2 = Me, i-Pr, cyclohexyl, Ph] were synthesized, characterized and screened for their antioxidant activity, using six antioxidant anal. assays comparatively to reference compounds, ascorbic acid and quercetin. The results indicated that several compounds I demonstrated strong antioxidant activity in DPPH, ABTS, H2O2 and lipid peroxidation assays where some of them were either as active as or more active than reference compounds However, all compounds I were largely less active than references compounds in the reducing power assay. The thiourea moiety probably played a crucial role in antioxidant activity of target compounds I, as a thiolate ion. The most favorable R1 groups were hydrogen and Me, followed by Ph and benzyl, whereas most favorable R2 group was iPr, followed by Ph and Me. The combination of benzothiadiazine ring with sulfonylthiourea moieties led to valuable new antioxidants, which could be used in treatment or prevention of certain diseases or in field of cosmetics, which needed further investigations in future. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Application In Synthesis of Isopropylisothiocyanate).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of Isopropylisothiocyanate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics