Target exposure values with regard to repeated dose toxicity in the framework of an easy-to-use workplace control scheme was written by Roller, M.. And the article was included in Schriftenreihe der Bundesanstalt fuer Arbeitsschutz und Arbeitsmedizin, Forschung in 2005.Recommanded Product: Ethyl 3-ethoxypropanoate The following contents are mentioned in the article:
By computer search, about 170 substances were found in the data base IUCLID which satisfied the following conditions: no MAK-value existent, no category 1 or 2 classification of mutagenicity, carcinogenicity or toxicity to reproduction, at least one IUCLID entry of an inhalation study of more than one day duration. Ninety nine of these substances could be grouped into four classes of chronic toxicity after target exposure values were derived with methods similar to the German ARW-concept. The allocation of the substances to the classes of chronic toxicity – based on IUCLID data – was compared with the allocation of the substances to the hazard bands of the British system COSSH Essentials – based on R-phrases. For about 2 thirds of the substances the uncertainty of the target exposure value and the class allocation is limited due to less satisfying input data. Despite the uncertainties, the anal. showed that in the sense of health protection not only R-phrases but also further toxicol. information should be incorporated into simple concepts of control methods, e.g. in terms of target exposure values, if derivation or control of formal occupational exposure limit values is not feasible. This study involved multiple reactions and reactants, such as Ethyl 3-ethoxypropanoate (cas: 763-69-9Recommanded Product: Ethyl 3-ethoxypropanoate).
Ethyl 3-ethoxypropanoate (cas: 763-69-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: Ethyl 3-ethoxypropanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics