Catalyst-free Hydrophosphinylation of Isocyanates and Isothiocyanates under Low-Added-Solvent Conditions was written by Huke, Cameron D.;Taylor, Laurence J.;Argent, Stephen P.;Kays, Deborah L.. And the article was included in ACS Sustainable Chemistry & Engineering in 2021.Recommanded Product: Isopropylisothiocyanate The following contents are mentioned in the article:
Phosphinecarboxamides R1R2P(O)CXNHR3 (R1, R2 = Ph, iPr, OEt, OMe; R3 = aryl, iPr, tBu, n-Pr, C6H13, PhCH2, Cy, 2-furyl; X = O, S) were prepared by green, catalyst-free, low-solvent hydrophosphination of isocyanates R3N:C:X with secondary phosphine oxides and dialkyl phosphites R1R2P(O)H. A range of phosphorus nucleophiles including secondary phosphine oxides HP(O)R2 (R = Ph, iPr), phosphites HP(O)(OR)2 (R = Me, Et), and Me phenylphosphinate were tested. The procedure tolerated isocyanates and isothiocyanates featuring a wide range of substituents, and with use of 4 equiv of 2-methyltetrahydrofuran (2-MeTHF), solid substrates can be utilized. Twenty-five compounds were prepared, with improved functional group tolerance compared to previous methods allowing access to new compounds (16 are novel). Facile scale up and simple reaction conditions make this a straightforward and practical methodol. for obtaining phosphorus analogs of ureas and thioureas, which are challenging to synthesize by other methods. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Recommanded Product: Isopropylisothiocyanate).
Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: Isopropylisothiocyanate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics