Formulation and evaluation of hydrophobic polymer based matrix sustained release tablets of captopril was written by Mishra, Shreyash;Upadhyay, Pranav Kumar. And the article was included in European Journal of Biomedical and Pharmaceutical Sciences in 2022.Electric Literature of C21H44O5 The following contents are mentioned in the article:
A review. The purpose of the present study was to prepare oral sustained release matrix tablets of highly water soluble drug, Captopril using a hydrophobic polymer compritol (glyceryl behenate) and to evaluate the effect of hydrophobic polymer and effect of methods of preparation on the release of the drug The tablets were prepared by direct compression, wet granulation techniques. The matrix tablets were evaluated for various parameters as phys. appearance, dimensions, hardness, weight variation, friability, drug content, in vitro dissolution studies. Also the matrix tablets prepared by hot melt granulation showed more effective retarded release rate than tablets prepared by direct compression and wet granulation techniques. Compritol 888 ATO can be used as a matrix former to sustain the release of water soluble drugs. Tizanidine hydrochloride tablets were prepared by melt direct compression technique using xanthum gum, glyceryl behenate, glyceryl monostearate and stearic acid in different proportion. Formulated sustend release tablets were evaluated for appearance, dimensions (diameter and thickness), weight varation, hardness, friability, drug content and in-vitro release of Tizanidine hydrochloride. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Electric Literature of C21H44O5).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Electric Literature of C21H44O5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics