Design, characterization and evaluation of floating microencapsules of ilaprazole by hot melt granulation method was written by Kajale, Archana D.;Gawande, Shilpa R.;Channawar, Madhuri A.;Raut, Pratiksha;Junghari, Kalyani;Satpute, Snehal. And the article was included in Pharmaceutical and Chemical Journal in 2022.Formula: C21H44O5 The following contents are mentioned in the article:
Microencapsulation is described as a process of enclosing micron-sized particles of solids or droplets of liquids or gasses in an inert shell, which in turn isolates and protects them from the external environment. Hot-melt granulation (HMG) has gained interest in the pharmaceutical field as a processing technol. capable of producing solid dispersions with a high degree of drug-polymer interactions. The simultaneous mech. and thermal shear of samples achieved by HMG can noticeably modify drug properties such as solubility, poor taste, and flow-ability, while producing sustained drug delivery systems. In Hot Melt Granulation Amount of meltable binder is 10%-30% weight/weight with respect to that of fine solid particles is used. A Meltable binder suitable for melt a granulation has a m.p. typically within the range of 60-80 °C. Hydrophilic Meltable binders are used for preparation of immediate-release dosage forms while the hydrophobic Meltable binders are preferred for prolonged-release formulations. The current work elaborates the mechanism of hot melt granulation over traditional method for sustained release of drug and long lasting effect. In the present study stearic acid, Glyceryl monosterate, Cetyl alc. were used as base and various polymers like HPMC K100 M, Guargum, Xanthum gum, were used in various concentrations From this formulations HPMC K100 M in the concentration of 2% (I12) gives sustain drug release as 100.76% for 12 h and follows zero order kinetics. Where other polymers i.e. Xanthum gum Guargum, were not able to retain the drug release for 12 h in various concentrations This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Formula: C21H44O5).
Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Formula: C21H44O5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics