Metabolomics analysis of the potential toxicological mechanisms of diquat dibromide herbicide in adult zebrafish (Danio rerio) liver was written by Xiao, Ye;Lin, Xiang;Zhou, Meilan;Ren, Tianyu;Gao, Ruili;Liu, Zhongqun;Shen, Wenjing;Wang, Rong;Xie, Xi;Song, Yanting;Hu, Wenting. And the article was included in Fish Physiology and Biochemistry in 2022.Recommanded Product: Glyceryl monostearate The following contents are mentioned in the article:
Although diquat is a widely used water-soluble herbicide in the world, its sublethal adverse effects to fish have not been well characterised. In this study, histopathol. examination and biochem. assays were applied to assess hepatotoxicity and combined with gas chromatog.-mass spectrometry (GC-MS)-based metabolomics anal. to reveal overall metabolic mechanisms in the liver of zebrafish (Danio rerio) after diquat exposure at concentrations of 0.34 and 1.69 mg·L-1 for 21 days. Results indicated that 1.69 mg·L-1 diquat exposure caused cellular vacuolisation and degeneration with nuclear abnormality and led to the disturbance of antioxidative system and dysfunction in the liver. No evident pathol. injury was detected, and changes in liver biochem. were not obvious in the fish exposed to 0.34 mg·L-1 diquat. Multivariate statistical anal. revealed differences between profiles obtained by GC-MS spectrometry from control and two treatment groups. A total of 17 and 22 metabolites belonging to different classes were identified following exposure to 0.34 and 1.69 mg·L-1 diquat, resp. The metabolic changes in the liver of zebrafish are mainly manifested as inhibition of energy metabolism, disorders of amino acid metabolism and reduction of antioxidant capacity caused by 1.69 mg·L-1 diquat exposure. The energy metabolism of zebrafish exposed to 0.34 mg·L-1 diquat was more inclined to rely on anaerobic glycolysis than that of normal zebrafish, and interference effects on lipid metabolism were observed The metabolomics approach provided an innovative perspective to explore possible hepatic damages on fish induced by diquat as a basis for further research. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Recommanded Product: Glyceryl monostearate).
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