Formulation and modification of physicochemical parameters of p-Coumaric acid by cyclodextrin nanosponges was written by Kumar, Anil;Rao, Rekha. And the article was included in Journal of Inclusion Phenomena and Macrocyclic Chemistry in 2022.Application In Synthesis of Diphenyl carbonate The following contents are mentioned in the article:
Reactive oxygen species triggered oxidative stress contributes to the pathogenesis of numerous ailments such as myocardial infraction, inflammation, atherosclerosis, and pigmentation disorders. ROS scavengers, particularly natural bioactives are one of the possible options to reduce this stress. However, these bioactives possess certain formulation challenges owing to their poor solubility, stability, and bioavailability. Therefore, the design of a stable formulation that can deal these challenges, while preserving the antioxidant efficacy is of great significance. In this view, the current study was aimed at fabrication of p-Coumaric acid loaded nanosponges employing melt method. The spectroscopy resulting nanosponges were appropriately characterized using Fourier transform IR spectroscopy, X-ray powder diffraction, differential scanning calorimetry, thermogravimetric anal., NMR, FE-SEM (field emission SEM) and TEM (transmission electron microscopy). The particle size of PCA-CDNS (p-Coumaric acid nanosponges) was in nano range, with low PDI (polydispersity index), acceptable zeta potential and delayed release. Mol. docking studies for PCA using mushroom tyrosinase (TYR) were also carried out. Further, the antioxidant and antityrosinase studies were also performed. In nutshell, the findings herein revealed that encasement of PCA in NS led to an enhancement in efficacy of this bioactive in terms of safety, solubility, and release, while preserving its antioxidant and antityrosinase effects. On the basis of the present results, we expect that PCA nanosponges can be seen as promising carriers for addressing depigmention, particularly associated with ROS overexpression. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Application In Synthesis of Diphenyl carbonate).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application In Synthesis of Diphenyl carbonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics