Volatilomic Signatures of AGS and SNU-1 Gastric Cancer Cell Lines was written by Slefarska-Wolak, Daria;Heinzle, Christine;Leiherer, Andreas;Ager, Clemens;Muendlein, Axel;Mezmale, Linda;Leja, Marcis;Corvalan, Alejandro H.;Drexel, Heinz;Krolicka, Agnieszka;Shani, Gidi;Mayhew, Christopher A.;Haick, Hossam;Mochalski, Pawel. And the article was included in Molecules in 2022.Electric Literature of C15H22O2 The following contents are mentioned in the article:
In vitro studies can help reveal the biochem. pathways underlying the origin of volatile indicators of numerous diseases. The key objective of this study is to identify the potential biomarkers of gastric cancer. For this purpose, the volatilomic signatures of two human gastric cancer cell lines, AGS (human gastric adenocarcinoma) and SNU-1 (human gastric carcinoma), and one normal gastric mucosa cell line (GES-1) were investigated. More specifically, gas chromatog. mass spectrometry has been applied to pinpoint changes in cell metabolism triggered by cancer. In total, ten volatiles were found to be metabolized, and thirty-five were produced by cells under study. The volatiles consumed were mainly six aldehydes and two heterocyclics, whereas the volatiles released embraced twelve ketones, eight alcs., six hydrocarbons, three esters, three ethers, and three aromatic compounds The SNU-1 cell line was found to have significantly altered metabolism in comparison to normal GES-1 cells. This was manifested by the decreased production of alcs. and ketones and the upregulated emission of esters. The AGS cells exhibited the increased production of Me ketones containing an odd number of carbons, namely 2-tridecanone, 2-pentadecanone, and 2-heptadecanone. This study provides evidence that the cancer state modifies the volatilome of human cells. This study involved multiple reactions and reactants, such as 2-Ethylhexyl benzoate (cas: 5444-75-7Electric Literature of C15H22O2).
2-Ethylhexyl benzoate (cas: 5444-75-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C15H22O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics