“In vivo” effects of acetylsalicylic acid and two ether derived compounds on primary immune response and lymphoblastic transformation was written by Barasoain, I.;Rojo, J. M.;Portoles, A.. And the article was included in Immunopharmacology in 1980.HPLC of Formula: 5003-48-5 The following contents are mentioned in the article:
The in vivo effects of acetylsalicylic acid (I) [50-78-2], Benorilate [5003-48-5], (II) and Eterilate [62992-61-4] (III) on lymphoblastic transformation and primary immune response were studied in mice. The humoral response in Benorilate- and Eterilate-treated mice was 40-50% lower than that of the controls, whereas in I-treated mice the response was only 25% inhibited. The number of Ig synthesizing cells was neither reduced by I nor by its derivatives, although indomethacin treatments (used for comparative purposes) inhibited by 40% the number of direct plaque-forming cells on the days tested. Mitogen-induced proliferation of spleen lymphocytes was also inhibited in the treated mice; these inhibitions were negligible in the case of cells from I treated mice activated by concanavalin A and slight in cells from Benorilate-treated mice activated by bacterial lipopolysaccharide. When lymphocytes from drug-treated animals were further cultured in the presence of the same drug, a variable inhibition of mitogen-induced proliferation was observed These different in vivo effects of I and the 2 ether derivatives and indomethacin may be due to a distinct action on diverse lymphocyte subpopulations altering their cellular collaborative interactions or modifying the prostaglandin availability. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5HPLC of Formula: 5003-48-5).
4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 5003-48-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics