Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery was written by Rust, Tarik;Jung, Dimitri;Hoppe, Axel;Schoppa, Timo;Langer, Klaus;Kuckling, Dirk. And the article was included in ACS Applied Polymer Materials in 2021.Electric Literature of C13H10O3 The following contents are mentioned in the article:
In modern therapy, cutting side effects caused by the administration of drugs is one of the core challenges. One possible strategy is the delivery of a drug to the disease site by encapsulation into a polymeric matrix. Especially, light-responsive polymers are regarded as promising materials due to, e.g., the capability of tailored on-demand release in illuminated areas. In this work, a series of light-responsive backbone-degradable (co-)polymers were synthesized by polycondensation and polyaddition All obtained polymers showed rapid degradation in solution upon exposure to UV light as observed by size-exclusion chromatog. (SEC) and UV-visible (UV-vis) spectroscopy. Light-induced decomposition of films prepared from the polycarbonate was confirmed by UV-vis, surface plasmon resonance (SPR), and profilometry measurements. Depending on the incorporated comonomers, the functional co-polyurethanes exhibited either enhanced hydrophilicity or dual-responsiveness to light and redox environments, which was detected by SEC after treatment with a reducing agent. The formulation of nanoparticles from light-responsive polyurethanes proved the processability of the synthesized polymers, and dynamic light scattering (DLS) measurements confirmed the photo-induced degradation of the prepared particles. Water-soluble tetrazolium salt (WST-1) assays were carried out to evaluate the cytotoxic potential before and after irradiation This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Electric Literature of C13H10O3).
Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C13H10O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics