Bioderivatization as a concept for renewable production of chemicals that are toxic or poorly soluble in the liquid phase was written by Sattayawat, Pachara;Yunus, Ian Sofian;Jones, Patrik R.. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2020.HPLC of Formula: 112-14-1 The following contents are mentioned in the article:
Bio-based production technologies may complement or replace petroleum-based production of chems., but they face a number of tech. challenges, including product toxicity and/or water insolubility Plants and microorganisms naturally biosynthesize chems. that often are converted into derivatives with reduced toxicity or enhanced solubility Inspired by this principle, we propose a bioderivatization strategy for biotechnol. chems. production, defined as purposeful biochem. derivatization of intended target mols. As proof of principle, the effects of hydrophobic (e.g., esterification) and hydrophilic (e.g., glycosylation) bioderivatization strategies on the biosynthesis of a relatively toxic and poorly soluble chem., 1-octanol, were evaluated in Escherichia coli and Synechocystis sp. PCC 6803. The 1-octanol pathway was first optimized to reach product titers at which the host displayed symptoms of toxicity. Solvent overlay used to capture volatile products partially masked product toxicity. Regardless of whether solvent overlay was used, most strains with bioderivatization had a higher molar product titer and product yield, as well as improved cellular growth and glucose consumption, compared with strains without bioderivatization. The pos. effect on bioprodn. was observed with both the hydrophobic and hydrophilic strategies. Interestingly, in several combinations of genotype/induction strength, bioderivatization had a pos. effect on productivity without any apparent effect on growth. We attribute this to enhanced product solubility in the aqueous or solvent fraction of the bioreactor liquid phase (depending on the derivative and medium used), with consequent enhanced product removal. Overall, under most conditions, a benefit of bioprodn. was observed, and the bioderivatization strategy could be considered for other similar chems. as well. This study involved multiple reactions and reactants, such as Octyl acetate (cas: 112-14-1HPLC of Formula: 112-14-1).
Octyl acetate (cas: 112-14-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.HPLC of Formula: 112-14-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics