Recommanded Product: 609-08-5In 2021 ,《Intermolecular domino Michael/aldol reactions of α,β-unsaturated esters, aromatic aldehydes, and various nucleophiles promoted with a catalytic amount of a guanidine base in DMSO》 was published in Tetrahedron. The article was written by Morita, Shunya; Yoshimura, Tomoyuki; Matsuo, Jun-ichi. The article contains the following contents:
In DMSO, a catalytic amount of Barton’s base (2-t-butyl-1,1,3,3-tetramethylguanidine, BTMG) effectively catalyzed intermol. three-component reactions of α-unsaturated esters, aldehydes, and carbon-, sulfur-, or nitrogen-pronucleophiles to give three-component addition products with the formation of two new σ-bonds: pronucleophiles and aldehydes reacted with α,β-unsaturated esters at their β-positions and α-positions, resp. Mechanism studies suggested that these reactions proceeded by the first intermol. Michael addition of anionic nucleophiles that were formed from pronucleophiles with a catalytic amount of BTMG, followed by intermol. aldol reactions of transient ester enolates even in the presence of more than stoichiometric amounts of acidic pronucleophiles. High nucleophilicity over Bronsted basicity of transient enolates in polar solvents was observed for transient ester enolates rather than ketone enolates. In the part of experimental materials, we found many familiar compounds, such as Diethyl 2-methylmalonate(cas: 609-08-5Recommanded Product: 609-08-5)
Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Recommanded Product: 609-08-5
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics