Category: esters-buliding-blocksIn 2021 ,《Synthesis of the C1-C27 Fragment of Stambomycin D Validates Modular Polyketide Synthase-Based Stereochemical Assignments》 was published in Organic Letters. The article was written by Lim, Jieyan; Chintalapudi, Venkaiah; Gudmundsson, Haraldur G.; Tran, Minh; Bernasconi, Alice; Blanco, Araceli; Song, Lijiang; Challis, Gregory L.; Anderson, Edward A.. The article contains the following contents:
The stambomycins are a family of bioactive macrolides isolated from Streptomyces ambofaciens. Aside from two stereocenters installed through cytochrome P 450 oxidations, their stereochem. has been predicted by sequence anal. of the polyketide synthase. We report a synthesis of the C1-C27 fragment (I) of stambomycin D, the spectroscopic data of which correlates well with that of the natural product, further validating predictive sequence anal. as a powerful tool for stereochem. assignment of complex polyketide natural products.Diethyl 2-methylmalonate(cas: 609-08-5Category: esters-buliding-blocks) was used in this study.
Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics