SDS of cas: 936-03-8On September 17, 1999 ,《Efficient cyclization of ω-oxo-α,β-unsaturated esters using lithium thiolate-initiated Michael-aldol tandem reaction》 was published in Tetrahedron Letters. The article was written by Ono, Masashi; Nishimura, Katsumi; Nagaoka, Yasuo; Tomioka, Kiyoshi. The article contains the following contents:
The reaction of ω-oxo-α,β-unsaturated esters with lithium thiolates afforded the Michael-aldol tandem cyclization products in good to perfect stereoselectivity depending on the nature of thiolates. For example, cyclization of 7-oxo-2-heptenoic acid Me ester with lithium phenylthiolate gave (1R,2S,6S)-rel-2-Hydroxy-6-(phenylthio)cyclohexanecarboxylic acid Me ester and (1R,2R,6S)-rel-2-Hydroxy-6-(phenylthio)cyclohexanecarboxylic acid Me ester. The latter were transformed into cis-2-hydroxycyclohexanecarboxylic acid Me ester and cis-2-hydroxycyclohexanecarboxylic acid Me ester, resp.Cis-methyl 2-hydroxycyclohexanecarboxylate(cas: 936-03-8SDS of cas: 936-03-8) was used in this study.
Cis-methyl 2-hydroxycyclohexanecarboxylate(cas: 936-03-8) belongs to esters. Esters are more polar than ethers but less polar than alcohols. SDS of cas: 936-03-8 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics