Quality Control of tert-Butyl (5-aminopentyl)carbamateIn 2021 ,《In vitro and in vivo degradation of programmed cell death ligand 1 (PD-L1) by a proteolysis targeting chimera (PROTAC)》 appeared in Bioorganic Chemistry. The author of the article were Wang, Yubo; Zhou, Yuanyuan; Cao, Sheng; Sun, Yue; Dong, Zhiqiang; Li, Chen; Wang, Haoran; Yao, Yuhong; Yu, Haiyan; Song, Xiangyi; Li, Ming; Wang, Jiefu; Wei, Mingming; Yang, Guang; Yang, Cheng. The article conveys some information:
Immunotherapy via immune checkpoints blockade has aroused the attention of researchers worldwide. Inhibition of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction has been one of the most promising immunotherapy strategies. Several neutralizing antibodies targeting this interaction have been developed, which have already achieved considerable clin. success. Addnl., numerous pharmaceutical companies have been committed to develop small mols. which could block the interaction between PD-1 and PD-L1. In this study, a novel PROTAC mol. 21a was developed, and effectively induced the degradation of PD-L1 protein in various malignant cells in a proteasome-dependent manner. Moreover, compound 21a could significantly reduce PD-L1 protein levels of MC-38 cancer cells in vivo, by which promoted the invasion of CD8+ T cells and inhibited the growth of MC-38 in vivo. This PROTAC mol. could be used as a novel and alternative strategy for cancer immunotherapy. In the experiment, the researchers used tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Quality Control of tert-Butyl (5-aminopentyl)carbamate)
Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Quality Control of tert-Butyl (5-aminopentyl)carbamate
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