Li, Yantao; Shao, Qianzhen; He, Hengchi; Zhu, Chengjian; Xue, Xiao-Song; Xie, Jin published their research in Nature Communications on December 31 ,2022. The article was titled 《Highly selective synthesis of all-carbon tetrasubstituted alkenes by deoxygenative alkenylation of carboxylic acids》.COA of Formula: C9H8O4 The article contains the following contents:
The synthesis of all-carbon tetrasubstituted olefins under mild reaction conditions is challenging because of the inevitable issues including significant steric hindrance and the uncontrolled Z/E stereoselectivity. In this paper, authors report the synthesis of all-carbon tetrasubstituted alkenes from readily available carboxylic acids and alkenyl triflates with the synergistic catalysis of cyclo-octa-1,5-diene(tetramethyl-1,4-benzoquinone)nickel and visible light under an air atm., thus avoiding the need for a glovebox or a Schlenk line. A wide range of aromatic carboxylic acids and cyclic and acyclic alkenyl triflates underwent the C-C coupling process smoothly, forming structurally diverse alkenes stereospecifically in moderate to good yields. The practicality of the method is further illustrated by the late-stage modification of complex mols., the one pot synthesis and gram-scale applications. This is an important step towards the valuable utilization of carboxylic acids, and it also simplifies the exptl. operation of metallophotoredox catalysis with moisture sensitive nickel(0) catalysis.3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0COA of Formula: C9H8O4) was used in this study.
3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.COA of Formula: C9H8O4 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics