Ronsisvalle, Simone; Panarello, Federica; Spadaro, Angelo; Franchini, Silvia; Pappalardo, Matteo; Guccione, Salvatore; Basile, Livia published an article in 2020, the title of the article was Pharmacological properties and biochemical mechanisms of μ-opioid receptor ligands might be due to different binding poses: MD studies.Related Products of 517-23-7 And the article contains the following content:
Central and peripheral analgesia without adverse effects relies on the identification of μ-opioid agonists that are able to activate basal antinociceptive pathways. Recently developed μ-selective benzomorphan agonists that are not antagonized by naloxone do not activate G-proteins and β-arrestins. Which pathways do μ receptors activate How can each of them be selectively activated What role is played by allosteric binding sites. Mol. modeling studies characterize the amino acid residues involved in the interaction with various classes of endogenous and exogenous ligands and with agonists and antagonists. Critical binding differences between various classes of agonists with different pharmacol. profiles have been identified. MML series binding poses may be relevant in the search for an antinociception agent without side effects. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Related Products of 517-23-7
The Article related to mu opioid receptor ligands antinociception, mor, allosteric site, benzomorphans, molecular dynamics, molecular modeling, opioid receptor, orthosteric site, Pharmacology: Structure-Activity and other aspects.Related Products of 517-23-7
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