On December 31, 2020, Setoguchi, Shuichi; Nagata-Akaho, Nami; Goto, Shotaro; Yamakawa, Hirofumi; Watase, Daisuke; Terada, Kazuki; Koga, Mitsuhisa; Matsunaga, Kazuhisa; Karube, Yoshiharu; Takata, Jiro published an article.Recommanded Product: Diethyl succinate The title of the article was Evaluation of photostability and phototoxicity of esterified derivatives of ubiquinol-10 and their application as prodrugs of reduced coenzyme Q10 for topical administration. And the article contained the following:
Ubiquinol-10 (UqH-10), the fully reduced form of ubiquinone-10 (Uq-10, coenzyme Q10), is an antioxidant and is involved in energy production However, physicochem. disadvantages, such as rapid oxidation, water-insolubility, photoinstability, and phototoxicity, limit its application. We previously reported that UqH-10 1,4-bis-N,N-dimethylglycinate improved the oxidation susceptibility and poor bioavailability of UqH-10 in rats. Herein, we evaluated the photochem. properties of UqH-esterified derivatives (N,N-dimethylglycinate, hemi-succinate, ethylsuccinate, and hemi-glutarate). Photostability was examined by irradiation using artificial sunlight and monochromatic light. The concentration of each compound was determined using LC-MS/MS. Phototoxicity was assessed by singlet oxygen and superoxide assays. Delivery of UqH-10 via UqH-esters to the HaCaT human keratinocyte cell line was determined using LC-MS/MS. UqH-esters showed higher photostability to artificial sunlight than Uq-10 and UqH-10. Uq-10 and UqH-10 were rapidly degraded by monochromatic light at 279 nm, whereas UqH-esters were more stable. UVA and/or UVB irradiation generated high levels of singlet oxygen and superoxide in Uq-10, whereas UqH-esters were unreactive. Addnl., UqH-esters effectively delivered UqH-10 to HaCaT cells following efficient uptake in their ester forms and ester bond hydrolysis in the cells. In conclusion, UqH-ester derivatives exhibit higher photostability and lower phototoxicity compared with Uq-10 and UqH-10. The experimental process involved the reaction of Diethyl succinate(cas: 123-25-1).Recommanded Product: Diethyl succinate
The Article related to reduced coenzyme ubiquinol antioxidant photostability phototoxicity, coenzyme q, drug delivery, keratinocyte, photostability, phototoxicity, prodrug, skin, ubiquinol, Placeholder for records without volume info and other aspects.Recommanded Product: Diethyl succinate
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