On July 31, 2020, Burcu Guerdere, Meliha; Aydin, Ali; Yencilek, Belkiz; Ertuerk, Fatih; Oezbek, Oguz; Erkan, Sultan; Budak, Yakup; Ceylan, Mustafa published an article.Computed Properties of 517-23-7 The title of the article was Synthesis, Antiproliferative and Cytotoxic Activities, DNA Binding Features and Molecular Docking Study of Novel Enamine Derivatives. And the article contained the following:
Novel enamine derivatives were synthesized from the reaction of lactone and chalcones and their antiproliferative and cytotoxic activities against six cancer cell lines (e. g., HeLa, HT29, A549, MCF7, PC3 and Hep3B) and one normal cell lines (e. g., FL) were investigated along with their mode of interactions with CT-DNA. Most of the enamine derivatives with IC50 values of 86-168 μM demonstrated much stronger antiproliferative activity than the starting mols. against the cancer cells. While, among the enamine derivatives, four compounds displayed higher cytotoxic potency than the control drugs (5-fluorouracil and cisplatin) against the Hep3B cell lines, these compounds did not exhibit any significant toxicity against normal cells, FL. The UV/VIS spectral data suggest that eight compounds cause hypochromism with a slight bathochromic shift (∼6 nm), indicating that they bind to the DNA by way of an intercalative or minor groove binding mode. The binding constants of the compounds are in the range of 0.1×103 M-1-2.3×104 M-1. The antiproliferative activity of studied enamine derivatives could possibly be due to their DNA binding as well as their cytotoxic properties. In addition to these assays, the chalcones and enamine derivatives were investigated by mol. docking to calculate the synergistic effect of antiproliferative activities against six human cancer cell lines. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Computed Properties of 517-23-7
The Article related to enamine derivative antiproliferative cytotoxic activity dna binding mol docking, antiproliferative activity, chalcone, cytotoxicity, molecular docking, enamine, lactone, Placeholder for records without volume info and other aspects.Computed Properties of 517-23-7
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