On July 5, 2022, Gao, Ya; Qin, Wei; Tian, Ming-Qing; Zhao, Xuefei; Hu, Xu-Hong published an article.COA of Formula: C6H8O3 The title of the article was Defluorinative Alkylation of Trifluoromethyl Alkenes with Soft Carbon Nucleophiles Enabled by a Catalytic Amount of Base. And the article contained the following:
Direct manipulation of readily accessible trifluoromethyl alkenes (TAs) represents an attractive approach to the preparation of diversified fluorine-containing compounds In this study, defluorinative alkylation reactions of TAs with a broad array of soft carbon nucleophiles have been documented. Nucleophilic substitutions occur enabled by a catalytic amount of base, providing access to tertiary alkyl substituted gem-difluoroalkenes and 2-fluoro-4H-pyrans. By extending the nucleophiles to silyl enol ethers, defluorination can be achieved in the absence of base to give gem-difluoroalkenes. This process, which eliminates the requirement of organometallic reagents, transition metals, or strong bases for the C-F bond cleavage, is applicable to late-stage modification of complex mols. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).COA of Formula: C6H8O3
The Article related to gem difluoroalkene fluoro pyran preparation, trifluoromethyl alkene soft carbon nucleophile defluorinative alkylation, General Organic Chemistry: Synthetic Methods and other aspects.COA of Formula: C6H8O3
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