On March 15, 2013, Godage, Himali Y.; Riley, Andrew M.; Woodman, Timothy J.; Thomas, Mark P.; Mahon, Mary F.; Potter, Barry V. L. published an article.COA of Formula: C10H14O3 The title of the article was Regioselective Opening of myo-Inositol Orthoesters: Mechanism and Synthetic Utility. And the article contained the following:
Acid hydrolysis of myo-inositol 1,3,5-ortho-esters, apart from ortho-formates, exclusively affords the corresponding 2-O-acyl myo-inositol products, e.g. I, via a 1,2-bridged five-membered ring dioxolanylium ion intermediate observed by NMR spectroscopy. These C-2-substituted inositol derivatives provide valuable precursors for rapid and highly efficient routes to 2-O-acyl inositol 1,3,4,5,6-pentakis-phosphates and myo-inositol 1,3,4,5,6-pentakis-phosphate with biol. interesting and anticancer properties. Deuterium incorporation into the α-methylene group of such alkyl ester products (2-O-C(O)CD2R), when the analogous alkyl ortho-ester is treated with deuterated acid, is established utilizing the novel orthoester myo-inositol 1,3,5-ortho-butyrate as an example. Such deuterated ester products provide intermediates for deuterium-labeled synthetic analogs. Investigation into this selective formation of 2-O-ester products and the deuterium incorporation is presented with proposed mechanisms from NMR experiments The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).COA of Formula: C10H14O3
The Article related to deuterium labeled inositol cyclitol preparation hydrolysis regioselective ring opening, inositol regioselective ring opening mechanism acid hydrolysis anticancer, Carbohydrates: Alditols, Cyclitols, Glycerides and other aspects.COA of Formula: C10H14O3
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