On September 30, 2020, Rajmani Singh, Rahul Kumar; Karsili, Tolga N. V.; Srivastava, Radhey published an article.Related Products of 517-23-7 The title of the article was Copper-catalyzed enantioselective direct α-C-H amination of β-dicarbonyl derivatives with aryl hydroxylamines and mechanistic insights. And the article contained the following:
Authors report a novel and efficient Cu-catalyzed direct asym. amination of tertiary β-carbonyl compounds using aryl hydroxylamine as electrophilic nitrogen donor. The process facilitates the convenient and direct synthesis of chiral α-amino carbonyl derivatives, without the need for any post-reaction manipulation. This method reveals an effective strategy for the synthesis of enantioenriched α-C-H aminated derivatives which is hitherto challenging. The choice of the robust chiral indabox ligand was ascertained to be very crucial for the desired enantioselectivity in the contemporary transformation. The reaction mechanism is fully supported by ab initio electronic structure calculations The reaction is facile, efficient and performs well at room temperature with an enantiomeric excess (ee) up to 93%. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Related Products of 517-23-7
The Article related to anilino benzoyl tetrahydrofuranone preparation enantioselective copper catalyst, carbonyl beta lactone hydroxylamine amination, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Related Products of 517-23-7
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