On January 31, 1983, Van der Walle, H. B.; Waegemaekers, T.; Bensink, T. published an article.HPLC of Formula: 1985-51-9 The title of the article was Sensitizing potential of 12 di(meth)acrylates in the guinea pig. And the article contained the following:
The sensitizing potential of 12 di(meth)acrylates was investigated in the Guinea Pig Maximization Test and Freund’s Complete Adjuvant Test (FCAT). In these tests, the same (molar) concentration was used for intradermal induction. Dimethacrylates were moderate to strong sensitizers in the guinea pig. In diacrylates, no sensitization to diethylene glycol diacrylate [4074-88-8] was observed 1,2-ethanediol diacrylate [2274-11-5] And 1,6-hexanediol diacrylate [13048-33-4] sensitized a number of animals. The challenge reaction pattern of the FCAT with 1,4-butanediol diacrylate [1070-70-8], neopentanediol diacrylate [2223-82-7] and 5-pentanediol diacrylate [36840-85-4] differed form that commonly observed with sensitizers. Pos. reactions were seen only to the maximum nonirritant concentration at 24 h in the challenge at day 21. At 48 h and in the 2nd challenge at day 35, the reactivity had decreased or disappeared. This different reaction pattern made it difficult to classify these monomers with certainty as sensitizers. In most of the FCATs, a decrease in reactivity in successive challenges was found. Possible explanations for this decrease and for the different challenge reaction patterns of some diacrylates were discussed. The skin irritant capacity of di(meth)acrylates was estimated after 1 open application. Diacrylates were very strong irritants on guinea pig skin. Dimethacrylates were weak irritants. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).HPLC of Formula: 1985-51-9
The Article related to dimethacrylate allergy, skin irritation methacrylate, acrylate allergy, sensitization skin acrylate methacrylate, Toxicology: Chemicals (Household, Industrial, General) and other aspects.HPLC of Formula: 1985-51-9
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