On September 15, 2020, Eckert, Elisabeth; Mueller, Johannes; Hoellerer, Christine; Purbojo, Ariawan; Cesnjevar, Robert; Goeen, Thomas; Muench, Frank published an article.Quality Control of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was Plasticizer exposure of infants during cardiac surgery. And the article contained the following:
In the present study we investigated the internal exposure situation of infant patients to the plasticizers TEHTM (tri-2-ethylhexyl trimellitate) and DEHP (di-2-ethylhexyl phthalate). The study collective included 21 infant patients aged 2-22 mo that had to undergo cardiac surgery using cardio pulmonary bypass (CPB). Each patient, but one, received blood products during surgery. A special feature was that the used CPB tubings were exclusively plasticized with the alternative plasticizer TEHTM and were free of the standard plasticizer DEHP, that raises increasing toxicol. concern. The blood products were stored in DEHP plasticized blood bags. Blood and urine samples of each infant patient were analyzed before and after the surgery for the levels of the plasticizers DEHP and TEHTM and their metabolites. In general, the plasticizers were detected in the post-surgery blood samples only, with TEHTM in low levels (median 18.4μg/L) and DEHP in rather elevated levels (median 1046μg/L). With respect to the urine samples, TEHTM metabolites were not detected in any of the samples. DEHP metabolites were found in all urine samples, however, in significantly increased median levels in the post-surgery urine samples of the infants (increase factor 5-26). Thus, the present study clearly demonstrates the strong contribution of standard medical procedures to the internal plasticizer burden of patients. Particularly with regard to the suspected endocrine disrupting activities of the phthalate plasticizer DEHP, the elevated internal levels of this plasticizer and its metabolites in infants following cardiac surgery are alarming. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Quality Control of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
The Article related to plasticizer exposure human infant cardiac surgery, biomonitoring, cardio pulmonary bypass, dehp, medical devices, packed red blood cells, totm, urine, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Quality Control of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
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