Weber, Ulrich; Andre, Michael published an article in 1975, the title of the article was Synthesis of a [Glu5,Ala12,Ala18,Ala21] sheep insulin A chain by fragment condensation on a polymer support.Formula: C10H19NO4 And the article contains the following content:
[Glu5,Ala12,Ala18,-Ala21]sheep insulin-A-chain (I) was prepared in 9% yield by condensation of Boc-Glu(OCMe3)-Ala-Tyr(CH2Ph)-Cys(CHMe2)-N2H3, Boc-Cys(CHMe2)-Ala-Leu-Tyr-Gln-Leu, Boc-Cys(CHMe2)-Ala-Gly-Val, Boc-Cys(CHMe2)-OH, and Boc-Gly-Ile-Val-Glu(OCMe3)-Glu(OCMe3)-OH (Boc = Me3CO2C), which were prepared in 60-98% yields on an alanine polymer. The failure sequence peptides were separated by ion exchange chromatog. on DEAD-Sephadex and by chromatog. on Biogel P 4. Combination of I with natural B-chain gave insulin activities comparable to that obtained with natural A-chain. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Formula: C10H19NO4
The Article related to insulin a analog sheep, Synthesis of Amino Acids, Peptides, and Proteins: Peptides and other aspects.Formula: C10H19NO4
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