On October 1, 2015, Brownstein, Michael J. published a patent.Reference of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the patent was Preparation of substituted azetidinone derivatives for use in the treatment of neurodegenerative diseases. And the patent contained the following:
Title compounds I [A = carboxylic acid, ester, or amide; D = carboxylic acid, ester, amide, alc., or thiol; R1 = H or alkyl; R2 = H, CN, halo, alkyl, etc.; R3 = (un)substituted amino, amido, acylamido, etc.], and their pharmaceutically acceptable salts, are prepared and disclosed for use in the treatment of neurodegenerative diseases. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in Via receptor binding assays, e.g., II demonstrated an IC50 value of 2.92 nM. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Reference of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate
The Article related to azetidinone preparation neurodegenerative disease, Heterocyclic Compounds (One Hetero Atom): 4-Membered Rings and other aspects.Reference of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics