Rosowsky, Andre; Forsch, Ronald; Uren, Jack; Wick, Michael published an article in 1981, the title of the article was Methotrexate analogs. 14. Synthesis of new γ-substituted derivatives as dihydrofolate reductase inhibitors and potential anticancer agents.Recommanded Product: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate And the article contains the following content:
The γ-tert-butyll ester (I) [79640-76-9], γ-hydrazide (II) [79640-75-8], γ-butylamide (III) [79640-74-7], and γ-benzylamide (IV) [71074-45-8] derivatives of methotrexate (MTX) were synthesized from 4-amino-4-deoxy-N10-methylpteroic acid [19741-14-1] and the appropriate blocked L-glutamic acid precursors with the aid of the peptide bond forming reagent di-Et phosphorocyanidate. The affinity of these side chain modified products for dihydrofolate reductase [9002-03-3] from Lactobacillus casei and L1210 mouse leukemic cells was determined spectrophotometrically or by competitive radioligand binding assay, and their cytotoxicity was evaluated against L1210 leukemic cells in culture. The results provide continuing support for the view that the γ-terminal region of the MTX side chain is an attractive site for mol. modification of this anticancer agent. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Recommanded Product: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate
The Article related to methotrexate analog preparation anticancer, dihydrofolate reductase inhibitor methotrexate analog, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Recommanded Product: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate
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