On August 11, 2017, Deng, Zeping; Chen, Fangjun published a patent.Formula: C9H8F2O2 The title of the patent was Preparation method of 2-(2,6-difluorobenzyl)pyrrolidine. And the patent contained the following:
The method relates to using 2-(2,6-difluorophenyl)acetic acid as initial material, carrying out esterification under action of catalyst, coupling in presence of alkali, opening loop with reducing agents, closing loop in presence of alkali, and reducing with reducing agent to obtain target product. The catalyst is one or more of 4-dimethylamino pyridine, p-Me Ph sulfonic acid, sulfuric acid, and/or thionyl chloride; the reducing agent is one or more of sodium borohydride, potassium borohydride, lithium borohydride, sodium cyano borohydride, lithium aluminum hydride, and/or borane. The compound is important medicine intermediate. The experimental process involved the reaction of Methyl 2-(2,6-difluorophenyl)acetate(cas: 872046-08-7).Formula: C9H8F2O2
The Article related to difluorobenzylpyrrolidine preparation, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.Formula: C9H8F2O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics