Ram, Ram N.; Sadanandan, Sandhya; Kumar Gupta, Dharmendra published an article in 2019, the title of the article was β,β,β-Trichloroethyl-NH-Enamine as Viable System for 5-Endo-trig Radical Cyclization via Multifaceted CuI-CuII Redox Catalysis: Single Step Synthesis of Multi-Functionalized NH-Pyrroles.Product Details of 517-23-7 And the article contains the following content:
A mild and regioselective copper-catalyzed direct synthesis of multi-substituted and functionalized NH-pyrroles was reported in high yields from diverse β,β,β-trichloroethyl-NH-enamines via a novel 5-endo-trig radical cyclization mode, previously known to be unviable in the enamine system. An approach to transform a geometrically ‘disfavored to favored’ 5-endo-trig radical cyclization mode in NH-enamine systems via multifaceted CuI-CuII redox catalysis generating radicals, preventing dehalogenative reduction of radical precursors and dehydrohalogenating the 5-endo-trig cyclized products was demonstrated exptl. With wider substrate scope, this method incorporated halo-, NH- and carbonyl functionalities besides alkyl, aryl and heteroaryl substituents in the pyrrole unit easily. These difficult 3-halo-NH-pyrroles are potential sources for natural products, agrochems., pharmaceuticals and organometallic chem. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Product Details of 517-23-7
The Article related to trichloroethyl enamine preparation copper catalyst regioselective radical cyclization, chloropyrrole preparation green chem, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.Product Details of 517-23-7
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics