Yu, Eric; Mangunuru, Hari P. R.; Telang, Nakul S.; Kong, Caleb J.; Verghese, Jenson; Gilliland, Stanley E. III; Ahmad, Saeed; Dominey, Raymond N.; Gupton, B. Frank published an article in 2018, the title of the article was High-yielding continuous-flow synthesis of antimalarial drug hydroxychloroquine.Synthetic Route of 517-23-7 And the article contains the following content:
Numerous synthetic methods for the continuous preparation of fine chems. and active pharmaceutical ingredients (API’s) have been reported in recent years resulting in a dramatic improvement in process efficiencies. Herein authors report a highly efficient continuous synthesis of the antimalarial drug hydroxychloroquine (HCQ). Key improvements in the new process include the elimination of protecting groups with an overall yield improvement of 52% over the current com. process. The continuous process employs a combination of packed bed reactors with continuous stirred tank reactors for the direct conversion of the starting materials to the product. This high-yielding, multigram-scale continuous synthesis provides an opportunity to achieve increase global access to hydroxychloroquine for treatment of malaria. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Synthetic Route of 517-23-7
The Article related to hydroxychloroquine antimalarial drug continuous flow preparation, api manufacturing, antimalarial, flow chemistry, hydrogenation, hydroiodic acid, hydroxychloroquine, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Synthetic Route of 517-23-7
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