On April 22, 2010, Sugita, Kazuyuki; Ota, Masahiro published a patent.Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the patent was Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors. And the patent contained the following:
Title compounds, e.g., I [or their pharmacol. acceptable salts], etc., were prepared For example, reaction of Et [(trans)-7-chloro-5-[3-methoxy-2-(trifluoromethyl)phenyl]-2-thioxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetate (preparation given) with NH2NH2·H2O followed by cyclization with trifluoroacetic anhydride, separation using chiral HPLC and hydrolysis afforded (4R,6R)-I. In squalene synthase inhibition assays, the IC50 value of (4R,6R)-I was 0.88 nM. The invention compounds are claimed useful for the treatment of hypercholesterolemia, hyperlipidemia, etc. Pharmaceutical composition comprising (4R,6R)-I is disclosed. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate
The Article related to tricyclic heteroaryl preparation squalene synthase inhibitor, hypercholesterolemia hyperlipidemia treatment tricyclic heteroaryl preparation squalene synthase inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Name: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate
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