On February 28, 2022, Jayaraman, Vijay; Lee, D. John; Elad, Nadav; Vimer, Shay; Sharon, Michal; Fraser, James S.; Tawfik, Dan S. published an article.Product Details of 79642-50-5 The title of the article was A counter-enzyme complex regulates glutamate metabolism in Bacillus subtilis. And the article contained the following:
Abstract: Multi-enzyme assemblies composed of metabolic enzymes catalyzing sequential reactions are being increasingly studied. Here, we report the discovery of a 1.6 megadalton multi-enzyme complex from Bacillus subtilis composed of two enzymes catalyzing opposite (counter-enzymes) rather than sequential reactions: glutamate synthase (GltAB) and glutamate dehydrogenase (GudB), which make and break glutamate, resp. In vivo and in vitro studies show that the primary role of complex formation is to inhibit the activity of GudB. Using cryo-electron microscopy, we elucidated the structure of the complex and the mol. basis of inhibition of GudB by GltAB. The complex exhibits unusual oscillatory progress curves and is necessary for both planktonic growth, in glutamate-limiting conditions, and for biofilm growth, in glutamate-rich media. The regulation of a key metabolic enzyme by complexing with its counter enzyme may thus enable cell growth under fluctuating glutamate concentrations [graphic not available: see fulltext]. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Product Details of 79642-50-5
The Article related to bacillus glutamate metabolism gltab gudb, Microbial, Algal, and Fungal Biochemistry: Metabolism and Microbial Nutrition and other aspects.Product Details of 79642-50-5
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