On December 16, 2011, Kurono, Nobuhito; Ohtsuga, Kentaro; Wakabayashi, Masanori; Kondo, Tadahiro; Ooka, Hirohito; Ohkuma, Takeshi published an article.Category: esters-buliding-blocks The title of the article was Kinetic resolution of racemic α-tert-alkyl-α-hydroxy esters by enantiomer-selective carbamoylation. And the article contained the following:
Kinetic resolution of sterically hindered racemic α-tert-alkyl-α-hydroxy esters is performed by enantiomer-selective carbamoylation with the t-Bu-Box-Cu(II) catalyst (Box = bis(oxazoline)). The reaction with 0.5 equiv of n-C3H7NCO is carried out with a substrate-to-catalyst molar ratio of 500-5000 at -20 to 25 °C. The high enantiomer-discrimination ability of the catalyst achieves an excellent stereoselectivity factor (s = kfast/kslow) of 261 in the best case. A catalytic cycle for this reaction is proposed. The experimental process involved the reaction of Methyl 2-hydroxy-3,3-dimethylbutanoate(cas: 121129-31-5).Category: esters-buliding-blocks
The Article related to kinetic resolution enantioselective carbamoylation racemic hydroxy ester, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics